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Prolonged Consumption of Sweetened Beverages Lastingly Deteriorates Cognitive Functions and Reward Processing in Mice

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dc.abstract.enWe investigated the detrimental effects of chronic consumption of sweet or sweetened beverages in mice. We report that consumption of beverages containing small amounts of sucrose during several weeks impaired reward systems. This is evidenced by robust changes in the activation pattern of prefrontal brain regions associated with abnormal risk-taking and delayed establishment of decision-making strategy. Supporting these findings, we find that chronic consumption of low doses of artificial sweeteners such as saccharin disrupts brain regions’ activity engaged in decision-making and reward processes. Consequently, this leads to the rapid development of inflexible decisions, particularly in a subset of vulnerable individuals. Our data also reveal that regular consumption, even at low doses, of sweet or sweeteners dramatically alters brain neurochemistry, i.e., dopamine content and turnover, and high cognitive functions, while sparing metabolic regulations. Our findings suggest that it would be relevant to focus on long-term consequences on the brain of sweet or sweetened beverages in humans, especially as they may go metabolically unnoticed.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKursa, Miron
dc.contributor.authorFlorian, Cédrick
dc.contributor.authorHamelin, Héloïse
dc.contributor.authorHamed, Adam
dc.contributor.authorGranon, Sylvie
dc.contributor.authorPoizat, Ghislaine
dc.contributor.authorTaouis, Mohammed
dc.contributor.authorCallebert, Jacques
dc.contributor.authorRampon, Claire
dc.contributor.authorPittaras, Elsa
dc.date.accessioned2024-01-25T18:08:57Z
dc.date.available2024-01-25T18:08:57Z
dc.date.issued2022
dc.description.financePublikacja bezkosztowa
dc.description.number7
dc.description.volume32
dc.identifier.doi10.1093/CERCOR/BHAB274
dc.identifier.issn1047-3211
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/117228
dc.identifier.weblinkhttp://academic.oup.com/cercor/advance-article-pdf/doi/10.1093/cercor/bhab274/40323260/bhab274.pdf
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofCerebral Cortex
dc.relation.pages1365–1378
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enartificial sweetener
dc.subject.endecision-making
dc.subject.enprefrontal cortex
dc.subject.enrisk-taking
dc.subject.ensugar
dc.titleProlonged Consumption of Sweetened Beverages Lastingly Deteriorates Cognitive Functions and Reward Processing in Mice
dc.typeJournalArticle
dspace.entity.typePublication