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Bovine Serum Albumin – Hydroxyapatite Nanoflowers as Potential Local Drug Delivery System of Ciprofloxacin

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dc.abstract.enIntroduction: Hybrid nanoflowers are structures consisting of organic (enzymes, proteins, nucleic acids) and inorganic components (mostly metal phosphates) with a flower-like hierarchical structure. Novel hybrid nanoflowers based on bovine serum albumin (BSA) and hydroxyapatite (HA) were obtained and characterized. Study on BSA-HA nanoflowers as potential drug delivery system is reported for the first time. Methods: Embedding ciprofloxacin in the structure of hybrid nanoflowers was confirmed by ATR-FTIR and thermogravimetric analysis. The inorganic phase of the nanoflowers was determined by X-ray diffraction. UV‒Vis spectroscopy was used to evaluate the release profiles of ciprofloxacin from nanoflowers in buffer solutions at pH 7.4 and 5. The agar disk diffusion method was used to study the antibacterial activity of the synthesized nanoflowers against Staphylococcus aureus and Pseudomonas aeruginosa. Results: Bovine serum albumin – hydroxyapatite nanoflowers were obtained with diameters of ca. 1–2 µm. The kinetics of ciprofloxacin release from nanoflowers were described by the Korsmeyer-Peppas model. The antibacterial activity of the synthesized nanoflowers was demonstrated against S. aureus and P. aeruginosa, two main pathogens found in osteomyelitis. Conclusion: The formulated nanoflowers may act as an efficient local antibiotic delivery system. Due to the use of nonhazardous, biodegradable components and benign synthesis, hybrid nanoflowers are very promising drug delivery systems that could be applied in the treatment of skeletal system infections.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBilewicz, Renata
dc.contributor.authorPrześniak-Welenc, Marta
dc.contributor.authorStolarczyk, Krzysztof
dc.contributor.authorSadowska, Kamila
dc.contributor.authorBobrowska, Kornelia
dc.contributor.authorGolec, Piotr
dc.date.accessioned2024-01-24T18:45:40Z
dc.date.available2024-01-24T18:45:40Z
dc.date.copyright2023-11-08
dc.date.issued2023
dc.description.accesstimeAT_PUBLICATION
dc.description.financeŚrodki finansowe, o których mowa w art. 365 pkt. 2 ustawy
dc.description.versionFINAL_PUBLISHED
dc.description.volume18
dc.identifier.doi10.2147/IJN.S427258
dc.identifier.issn1176-9114
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/102482
dc.identifier.weblinkhttps://doi.org/10.2147/IJN.S427258
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofInternational journal of nanomedicine
dc.relation.pages6449 - 6467
dc.rightsCC-BY-NC
dc.sciencecloudnosend
dc.subject.enhybrid nanoflowers
dc.subject.enorganic‒inorganic nanoflowers
dc.subject.enosteomyelitis
dc.subject.enPseudomonas aeruginosa
dc.subject.enStaphylococcus aureus
dc.titleBovine Serum Albumin – Hydroxyapatite Nanoflowers as Potential Local Drug Delivery System of Ciprofloxacin
dc.typeJournalArticle
dspace.entity.typePublication