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High-Pressure Accelerated Enantioselective Addition of Indoles to Trifluoromethyl Ketones with a Low Loading of Chiral BINOL-Derived Phosphoric Acid

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cris.lastimport.scopus2024-02-12T20:50:38Z
dc.abstract.enThe effect of pressure (up to 10 kbar) on the Brønsted acid catalyzed enantioselective hydroxyalkylation of indoles with trifluoromethyl ketones was explored. The reaction was effectively accelerated at 9 kbar with a very low loading of a 1,1′-bi-2-naphthol (BINOL) -derived phosphoric acid (0.05–0.2 mol % of TRIP) and provided the products with high enantioselectivity (84–98 % ee).
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKwiatkowski, Piotr
dc.contributor.authorBiedrzycki, Michał
dc.contributor.authorKasztelan, Adrian
dc.date.accessioned2024-01-25T03:11:46Z
dc.date.available2024-01-25T03:11:46Z
dc.date.issued2017
dc.description.financeNie dotyczy
dc.description.number13
dc.description.volume9
dc.identifier.doi10.1002/CCTC.201700281
dc.identifier.issn1867-3880
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108487
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofChemCatChem
dc.relation.pages2453-2456
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enasymmetric catalysis
dc.subject.enBrønsted acids
dc.subject.enfluorine
dc.subject.enhigh-pressure chemistry
dc.subject.enorganocatalysis
dc.titleHigh-Pressure Accelerated Enantioselective Addition of Indoles to Trifluoromethyl Ketones with a Low Loading of Chiral BINOL-Derived Phosphoric Acid
dc.typeJournalArticle
dspace.entity.typePublication