Artykuł w czasopiśmie
Brak miniatury
Licencja
CC-BYCC-BY - Uznanie autorstwa
 

Novel Role of Mammalian Cell Senescence-Sustenance of Muscle Larvae of Trichinella spp.

Uproszczony widok
cris.lastimport.scopus2024-02-12T20:50:39Z
dc.abstract.enMuscle larva of the parasitic nematode Trichinella spp. lives in a portion of muscle fibre transformed to a nurse cell (NC). Based on our previous transcriptomic studies, NC growth arrest was inferred to be accompanied by cellular senescence. In the current study, NC was proven to display the following markers of senescence: high senescence-associated β-galactosidase activity, lipid deposition, DNA damage, and cell cycle inhibition. Moreover, the nuclear localization of Activator Protein 1 (c-Fos, c-Jun, and FosB), as well as the upregulation of numerous AP-1 target genes in the NC, remained in accord with AP-1 recently identified as a master transcription factor in senescence. An increase in reactive oxygen species generation and the upregulation of antioxidant defence enzymes, including glutathione peroxidases 1 and 3, catalase, superoxide dismutases 1 and 3, and heme oxygenase 1, indicated an ongoing oxidative stress to proceed in the NC. Interestingly, antioxidant defence enzymes localized not only to the NC but also to the larva. These results allowed us to hypothesize that oxidative stress accompanying muscle regeneration and larval antigenic properties lead to the transformation of a regenerating myofibre into a senescent cell. Cellular senescence apparently represents a state of metabolism that sustains the long-term existence of muscle larva and ultimately provides it with the antioxidant capacity needed during the next host colonization. Senotherapy, a therapeutic approach aimed at selective elimination of senescent cells, can thus be viewed as potentially effective in the treatment of trichinosis.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGoździk, Katarzyna
dc.contributor.authorDoligalska, Maria
dc.contributor.authorSkoneczny, Marek
dc.contributor.authorZIELIŃSKI, ZBIGNIEW
dc.contributor.authorDĄBROWSKA, MAGDALENA
dc.contributor.authorSIKORA, EWA
dc.contributor.authorCAŁKA-KRESA, MAŁGORZATA
dc.contributor.authorKĘPCZYŃSKA, AGNIESZKA
dc.date.accessioned2024-01-25T13:52:36Z
dc.date.available2024-01-25T13:52:36Z
dc.date.copyright2022-11-28
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.numberbrak
dc.description.versionFINAL_PUBLISHED
dc.description.volume2022
dc.identifier.doi10.1155/2022/1799839
dc.identifier.issn1942-0900
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/113966
dc.identifier.weblinkhttp://downloads.hindawi.com/journals/omcl/2022/1799839.pdf
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofOxidative Medicine and Cellular Longevity
dc.relation.pages1799839 (1-13)
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.plbrak
dc.titleNovel Role of Mammalian Cell Senescence-Sustenance of Muscle Larvae of Trichinella spp.
dc.typeJournalArticle
dspace.entity.typePublication