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A tetrahydroacridine derivative and its conjugate with gold nanoparticles: promising agents for the treatment of Alzheimer's disease

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cris.lastimport.scopus2024-02-12T20:46:12Z
dc.abstract.enA new tetrahydroacridine derivative (CHDA) with acetylcholinesterase inhibitory properties was synthesized. Using a range of physicochemical techniques, it was shown that the compound strongly adsorbs onto the surface of planar macroscopic or nanoparticulate gold, forming a nearly full monolayer. The adsorbed CHDA molecules reveal well-defined electrochemical behavior, being irreversibly oxidized to electroactive species. The CHDA also exhibits strong fluorescence, which is effectively quenched after adsorption onto gold via a static quenching mechanism. Both CHDA and its conjugate reveal considerable inhibitory properties against acetylcholinesterase activity, which is promising from the perspective of therapeutic application in the treatment of Alzheimer's disease. Moreover, both agents appear to be non-toxic as demonstrated using in vitro studies. On the other hand, conjugation of CHDA with nanoradiogold particles (Au-198) offers new potential diagnostic perspectives in medical imaging.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorMazur, Maciej
dc.contributor.authorMaurin, Jan
dc.contributor.authorWiktorska, Katarzyna
dc.contributor.authorChotkowski, Maciej
dc.contributor.authorZając, Dominika
dc.contributor.authorWojciechowski, Piotr
dc.contributor.authorKaczyńska, Katarzyna
dc.contributor.authorZawadzka, Anna
dc.contributor.authorMojzych, Ilona
dc.date.accessioned2024-01-24T18:13:33Z
dc.date.available2024-01-24T18:13:33Z
dc.date.issued2023
dc.description.financeNie dotyczy
dc.description.number25
dc.description.volume25
dc.identifier.doi10.1039/D3CP00767G
dc.identifier.issn1463-9076
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/101896
dc.identifier.weblinkhttp://pubs.rsc.org/en/content/articlepdf/2023/CP/D3CP00767G
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofPhysical Chemistry Chemical Physics
dc.relation.pages16796-16806
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enAlzheimer's disease
dc.subject.entetrahydroacridine derivative
dc.titleA tetrahydroacridine derivative and its conjugate with gold nanoparticles: promising agents for the treatment of Alzheimer's disease
dc.typeJournalArticle
dspace.entity.typePublication