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Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

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dc.abstract.enColloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size"clusters can be both stable enough to crystallize and sufficiently labile for further growth.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSzczerba, Daniel
dc.contributor.authorRousselin, Yoann
dc.contributor.authorMeyer, Michel
dc.contributor.authorHalasz, Ivan
dc.contributor.authorLucas, María del Carmen Marco de
dc.contributor.authorBazhenov, Vasilii
dc.contributor.authorGlaevecke, Philipp
dc.contributor.authorArhangelskis, Mihails
dc.contributor.authorGeoffroy, Nicolas
dc.contributor.authorChaumont, Denis
dc.contributor.authorTiti, Hatem M.
dc.contributor.authorDippel, Ann-Christin
dc.contributor.authorMouhtadi, Siham
dc.contributor.authorGutowski, Olof
dc.contributor.authorIvashko, Oleh
dc.contributor.authorSchwanen, Valérie
dc.contributor.authorDo, Jean-Louis
dc.contributor.authorTan, Davin
dc.contributor.authorSpoerk-Erdely, Petra
dc.contributor.authorHudspeth, Jessica M.
dc.contributor.authorKimber, Simon A. J.
dc.contributor.authorFriščić, Tomislav
dc.date.accessioned2024-01-25T18:47:43Z
dc.date.available2024-01-25T18:47:43Z
dc.date.issued2021
dc.description.financePublikacja bezkosztowa
dc.description.number40
dc.description.volume143
dc.identifier.doi10.1021/JACS.1C07186
dc.identifier.issn0002-7863
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/117936
dc.identifier.weblinkhttps://pubs.acs.org/doi/pdf/10.1021/jacs.1c07186
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofJournal of the American Chemical Society
dc.relation.pages16332-16336
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleReal-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate
dc.typeJournalArticle
dspace.entity.typePublication