Artykuł w czasopiśmie
Brak miniatury
Licencja
ClosedAccessDostęp zamknięty
 

Synthesis of RNA 5′-Azides from 2′-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide–Alkyne Cycloaddition Reactions

Uproszczony widok
cris.lastimport.scopus2024-02-12T20:45:40Z
dc.abstract.enCommercially available 2′-O-pivaloyloxymethyl (PivOM) phosphoramidites were employed in an SPS protocol for RNA 5′ azides. The utility of the N3-RNAs in CuAAC and SPAAC was demonstrated by RNA 5′ labeling, chemical ligation including fragment joining and cyclization, and bioconjugation. As a result, several new RNA conjugates that may be valuable tools for studies on biological events such as innate immune response (cyclic dinucleotides), post-transcriptional gene regulation (circular RNAs), or mRNA turnover (m7G capped RNAs) were obtained.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKowalska, Joanna
dc.contributor.authorJemielity, Jacek
dc.contributor.authorWarmiński, Marcin
dc.date.accessioned2024-01-26T09:26:55Z
dc.date.available2024-01-26T09:26:55Z
dc.date.issued2017
dc.description.financeNie dotyczy
dc.identifier.doi10.1021/ACS.ORGLETT.7B01591
dc.identifier.issn1523-7060
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/121316
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofOrganic Letters
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleSynthesis of RNA 5′-Azides from 2′-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide–Alkyne Cycloaddition Reactions
dc.typeJournalArticle
dspace.entity.typePublication