Artykuł w czasopiśmie
Brak miniatury
Licencja
ClosedAccessDostęp zamknięty
 

Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction

Uproszczony widok
cris.lastimport.scopus2024-02-12T20:42:21Z
dc.abstract.enPerturbed cellular protein homeostasis (proteostasis) and mitochondrial dysfunction play an important role in neurodegenerative diseases, however, the interplay between these two phenomena remains unclear. Mitochondrial dysfunction leads to a delay in mitochondrial protein import, causing accumulation of non-imported mitochondrial proteins in the cytosol and challenging proteostasis. Cells respond by increasing proteasome activity and molecular chaperones in yeast and C. elegans. Here, we demonstrate that in human cells mitochondrial dysfunction leads to the upregulation of a chaperone HSPB1 and, interestingly, an immunoproteasome-specific subunit PSMB9. Moreover, PSMB9 expression is dependent on the translation elongation factor EEF1A2. These mechanisms constitute a defense response to preserve cellular proteostasis under mitochondrial stress. Our findings define a mode of proteasomal activation through the change in proteasome composition driven by EEF1A2 and its spatial regulation, and are useful to formulate therapies to prevent neurodegenerative diseases.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSamluk, Łukasz
dc.contributor.authorChacinska, Agnieszka
dc.contributor.authorWarscheid, Bettina
dc.contributor.authorWasilewski, Michal
dc.contributor.authorOeljeklaus, Silke
dc.contributor.authorTsegaye, Biniyam
dc.contributor.authorElancheliyan, Praveenraj
dc.contributor.authorStępkowski, Tomasz M.
dc.contributor.authorKodroń, Agata
dc.contributor.authorSuppanz, Ida
dc.contributor.authorSerwa, Remigiusz A.
dc.contributor.authorKim, Minji
dc.date.accessioned2024-01-25T03:44:41Z
dc.date.available2024-01-25T03:44:41Z
dc.date.issued2023
dc.description.financePublikacja bezkosztowa
dc.description.number1
dc.description.volume14
dc.identifier.doi10.1038/S41467-023-39642-8
dc.identifier.issn2041-1723
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108982
dc.identifier.weblinkhttps://www.nature.com/articles/s41467-023-39642-8.pdf
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofNature Communications
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleImmunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction
dc.typeJournalArticle
dspace.entity.typePublication