Artykuł w czasopiśmie
Brak miniatury
Licencja
ClosedAccessDostęp zamknięty
 

Chromosome-level organization of the regulatory genome in the Drosophila nervous system

Uproszczony widok
dc.abstract.enPrevious studies have identified topologically associating domains (TADs) as basic units of genome organization. We present evidence of a previously unreported level of genome folding, where distant TAD pairs, megabases apart, interact to form meta-domains. Within meta-domains, gene promoters and structural intergenic elements present in distant TADs are specifically paired. The associated genes encode neuronal determinants, including those engaged in axonal guidance and adhesion. These long-range associations occur in a large fraction of neurons but support transcription in only a subset of neurons. Meta-domains are formed by diverse transcription factors that are able to pair over long and flexible distances. We present evidence that two such factors, GAF and CTCF, play direct roles in this process. The relative simplicity of higher-order meta-domain interactions in Drosophila, compared with those previously described in mammals, allowed the demonstration that genomes can fold into highly specialized cell-type-specific scaffolds that enable megabase-scale regulatory associations.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGambetta, Maria Cristina
dc.contributor.authorLevine, Michael S.
dc.contributor.authorJankowski, Aleksander
dc.contributor.authorMcCabe, Brian D.
dc.contributor.authorGuex, Nicolas
dc.contributor.authorRestrepo, Simon
dc.contributor.authorIseli, Christian
dc.contributor.authorCousin, Pascal
dc.contributor.authorRosa, Patrycja
dc.contributor.authorKhadka, Jenisha
dc.contributor.authorRodriguez, Daniel
dc.contributor.authorLeleu, Marion
dc.contributor.authorMalek, Héléna
dc.contributor.authorSmith, Rebecca C.
dc.contributor.authorMouginot, Marion
dc.contributor.authorLi, Xiao
dc.contributor.authorDorier, Julien
dc.contributor.authorMohana, Giriram
dc.date.accessioned2024-01-24T19:24:09Z
dc.date.available2024-01-24T19:24:09Z
dc.date.issued2023
dc.description.financePublikacja bezkosztowa
dc.description.number18
dc.description.volume186
dc.identifier.doi10.1016/J.CELL.2023.07.008
dc.identifier.issn0092-8674
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/103050
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S0092867423007419?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationcomputer and information sciences
dc.relation.ispartofCell
dc.relation.pages3826-3844.e26
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enDrosophila
dc.subject.enTAD
dc.subject.enchromosomal loop
dc.subject.engene regulation
dc.subject.engenome architecture
dc.subject.engenome organization
dc.subject.ennervous system
dc.subject.enneuron
dc.subject.entranscription
dc.titleChromosome-level organization of the regulatory genome in the Drosophila nervous system
dc.typeJournalArticle
dspace.entity.typePublication