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Fungal lifestyle reflected in serine protease repertoire.

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cris.lastimport.scopus2024-02-12T20:45:04Z
dc.abstract.enFungi are able to switch between different lifestyles in order to adapt to environmental changes. Their ecological strategy is connected to their secretome as fungi obtain nutrients by secreting hydrolytic enzymes to their surrounding and acquiring the digested molecules. We focus on fungal serine proteases (SPs), the phylogenetic distribution of which is barely described so far. In order to collect a complete set of fungal proteases, we searched over 600 fungal proteomes. Obtained results suggest that serine proteases are more ubiquitous than expected. From 54 SP families described in MEROPS Peptidase Database, 21 are present in fungi. Interestingly, 14 of them are also present in Metazoa and Viridiplantae – this suggests that, except one (S64), all fungal SP families evolved before plants and fungi diverged. Most representatives of sequenced eukaryotic lineages encode a set of 13–16 SP families. The number of SPs from each family varies among the analysed taxa. The most abundant are S8 proteases. In order to verify hypotheses linking lifestyle and expansions of particular SP, we performed statistical analyses and revealed previously undescribed associations. Here, we present a comprehensive evolutionary history of fungal SP families in the context of fungal ecology and fungal tree of life.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorPawłowska, Julia
dc.contributor.authorDziedzic, Agata
dc.contributor.authorMuszewska, Anna
dc.contributor.authorStepniewska-Dziubinska, Marta M.
dc.contributor.authorSteczkiewicz, Kamil
dc.contributor.authorGinalski, Krzysztof
dc.date.accessioned2024-01-25T01:40:52Z
dc.date.available2024-01-25T01:40:52Z
dc.date.issued2017
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.numberbrak
dc.description.versionFINAL_PUBLISHED
dc.description.volume7
dc.identifier.doi10.1038/S41598-017-09644-W
dc.identifier.issn2045-2322
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/107636
dc.identifier.weblinkhttps://www.nature.com/articles/s41598-017-09644-w
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofScientific Reports
dc.relation.pages9147
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.plbrak
dc.titleFungal lifestyle reflected in serine protease repertoire.
dc.typeJournalArticle
dspace.entity.typePublication