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A Global Review on Short Peptides: Frontiers and Perspectives

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dc.abstract.enPeptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide "drugs" initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorApostolopoulos, Vasso
dc.contributor.authorParang, Keykavous
dc.contributor.authorChai, Tsun-Thai
dc.contributor.authorElnagdy, Sherif
dc.contributor.authorMatsoukas, John
dc.contributor.authorNew, Roger
dc.contributor.authorZielenkiewicz, Piotr
dc.contributor.authorTang, Yefeng
dc.contributor.authorYoshiya, Taku
dc.contributor.authorLopez, Octavio Paredes
dc.contributor.authorParhiz, Hamideh
dc.contributor.authorPerera, Conrad O.
dc.contributor.authorPickholz, Monica
dc.contributor.authorRemko, Milan
dc.contributor.authorSaviano, Michele
dc.contributor.authorSkwarczynski, Mariusz
dc.contributor.authorZabrocki, Janusz
dc.contributor.authorAlKhazindar, Maha
dc.contributor.authorBarriga, Vanessa
dc.contributor.authorKelaidonis, Konstantinos
dc.contributor.authorSarasia, Elham Mousavinezhad
dc.contributor.authorToth, Istvan
dc.contributor.authorBojarska, Joanna
dc.contributor.authorWolf, Wojciech
dc.contributor.authorKaczmarek, Krzysztof
dc.date.accessioned2024-01-24T17:39:08Z
dc.date.available2024-01-24T17:39:08Z
dc.date.copyright2021-01-15
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number2
dc.description.versionFINAL_PUBLISHED
dc.description.volume26
dc.identifier.doi10.3390/MOLECULES26020430
dc.identifier.issn1420-3049
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/101574
dc.identifier.weblinkhttps://www.mdpi.com/1420-3049/26/2/430/pdf
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofMolecules
dc.relation.pages430
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enshort peptides
dc.subject.enconstrained amino acids and peptide (bio)mimetics
dc.subject.endrug design and drug
dc.subject.engene delivery
dc.subject.envaccines
dc.subject.enaptamers
dc.subject.encell-penetrating peptides
dc.subject.ensynthesis
dc.subject.enSARS-COV-2
dc.subject.encancer
dc.subject.enbilayer interactions
dc.subject.enaltered peptide ligands
dc.subject.enant
dc.subject.enagonists
dc.subject.endiketopiperazine
dc.subject.encosmeceuticals
dc.titleA Global Review on Short Peptides: Frontiers and Perspectives
dc.typeJournalArticle
dspace.entity.typePublication