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The Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression

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dc.abstract.enRecently, the possibility of cross-kingdom gene expression regulation by miRNAs from other species (“xenomiRs”), specifically from plants, has acquired scientific meaning. Based on the one of oldest methods for dealing with inflammation via the use of cabbage leaf compresses, we investigated the effects of Brassica oleracea derived miR172a on the potential human target gene encoding FAN (Factor Associated with Neutral Sphingomyelinase Activation) protein. In vitro experiments showed a decrease in FAN protein levels in both human and mouse cells transfected with bol-miRNA172a. As the FAN protein mediates inflammatory responses, the potential of miR172a to mitigate the inflammatory process was tested in a mouse model of rheumatoid arthritis. Animal studies showed the decreased oedema of inflamed paws in mouse with rheumatoid arthritis model induced after treatment with miR172a.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorŁukasik, Anna
dc.contributor.authorPączek, Leszek
dc.contributor.authorZielenkiewicz, Piotr
dc.contributor.authorZielenkiewicz, Urszula
dc.contributor.authorCudnoch-Jedrzejewska, Agnieszka
dc.contributor.authorPucia, Katarzyna
dc.contributor.authorKosowska, Anna
dc.contributor.authorKöhling, Iwona
dc.contributor.authorKasarello, Kaja
dc.date.accessioned2024-01-26T09:54:16Z
dc.date.available2024-01-26T09:54:16Z
dc.date.copyright2022-03-24
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.numberbrak
dc.description.versionFINAL_PUBLISHED
dc.description.volume13
dc.identifier.doi10.3389/FPHAR.2022.846830
dc.identifier.issn1663-9812
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/121870
dc.identifier.weblinkhttps://www.frontiersin.org/articles/10.3389/fphar.2022.846830/full
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofFrontiers in Pharmacology
dc.relation.pages846830 (1-8)
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enxenomiRs,
dc.subject.enrheumatoid arthritis,
dc.subject.eninflammation,
dc.subject.encollagen-induced arthritis,
dc.subject.enFAN protein
dc.titleThe Anti-Inflammatory Effect of Cabbage Leaves Explained by the Influence of bol-miRNA172a on FAN Expression
dc.typeJournalArticle
dspace.entity.typePublication