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Three-dimensional organization and dynamics of the genome

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cris.lastimport.scopus2024-02-12T20:40:43Z
dc.abstract.enGenome is a complex hierarchical structure, and its spatial organization plays an important role in its function. Chromatin loops and topological domains form the basic structural units of this multiscale organization and are essential to orchestrate complex regulatory networks and transcription mechanisms. They also form higher-order structures such as chromosomal compartments and chromosome territories. Each level of this intrinsic architecture is governed by principles and mechanisms that we only start to understand. In this review, we summarize the current view of the genome architecture on the scales ranging from chromatin loops to the whole genome. We describe cell-to-cell variability, links between genome reorganization and various genomic processes, such as chromosome X inactivation and cell differentiation, and the interplay between different experimental techniques.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSzałaj, Przemysław
dc.contributor.authorPlewczyński, Dariusz
dc.date.accessioned2024-01-26T10:52:17Z
dc.date.available2024-01-26T10:52:17Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.identifier.doi10.1007/S10565-018-9428-Y
dc.identifier.issn0742-2091
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/123359
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofCell Biology and Toxicology
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.en2018 Plewczyński
dc.titleThree-dimensional organization and dynamics of the genome
dc.typeJournalArticle
dspace.entity.typePublication