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Label-Free Mass Spectrometry-Based Proteomic Analysis in Lamb Tissues after Fish Oil, Carnosic Acid, and Inorganic Selenium Supplementation

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cris.lastimport.scopus2024-02-12T20:41:05Z
dc.abstract.enSelenium is an essential nutrient, building twenty five identified selenoproteins in humans known to perform several important biological functions. The small amount of selenium in the earth’s crust in certain regions along with the risk of deficiency in organisms have resulted in increasingly popular dietary supplementation in animals, implemented via, e.g., inorganic selenium compounds. Even though selenium is included in selenoproteins in the form of selenocysteine, the dietary effect of selenium may result in the expression of other proteins or genes. Very little is known about the expression effects modulated by selenium. The present study aimed to examine the significance of protein expression in lamb tissues obtained after dietary supplementation with selenium (sodium selenate) and two other feed additives, fish oil and carnosic acid. Label-free mass spectrometry-based proteomic analysis was successfully applied to examine the animal tissues. Protein-protein interaction network analysis of forty differently-expressed proteins following inorganic selenium supplementation indicated two significant clusters which are involved in cell adhesion, heart development, actin filament-based movement, plasma membrane repair, and establishment of organelle localization.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGawor, Andrzej
dc.contributor.authorRuszczyńska, Anna
dc.contributor.authorKonopka, Anna
dc.contributor.authorWryk, Grzegorz
dc.contributor.authorCzauderna, Marian
dc.contributor.authorBulska, Ewa
dc.date.accessioned2024-01-25T04:58:39Z
dc.date.available2024-01-25T04:58:39Z
dc.date.copyright2022-05-31
dc.date.issued2022
dc.description.accesstimeBEFORE_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number11
dc.description.versionFINAL_PUBLISHED
dc.description.volume12
dc.identifier.doi10.3390/ANI12111428
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/110804
dc.identifier.weblinkhttps://www.mdpi.com/2076-2615/12/11/1428/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofAnimals
dc.relation.pages1428
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enselenium
dc.subject.ensupplementation
dc.subject.enlabel-free mass spectrometry
dc.subject.enproteomics
dc.subject.enprotein-protein interactio
dc.titleLabel-Free Mass Spectrometry-Based Proteomic Analysis in Lamb Tissues after Fish Oil, Carnosic Acid, and Inorganic Selenium Supplementation
dc.typeJournalArticle
dspace.entity.typePublication