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Electroactive, mediating and thermosensitive microgel useful for covalent entrapment of enzymes and formation of sensing layer in biosensors

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cris.lastimport.scopus2024-02-12T20:41:21Z
dc.abstract.enThermosensitive microgel particles based on the polymeric network synthesized from N-isopropylacrylamide, sodium acrylate and N,N’-bisacryloylcystine havebeen functionalized with aminoferrocene, a mediatior, and a model enzyme-glucose oxidase (GOx). The product was very stable. A thin coating of that material has successfully attached to the glassy carbon electrode surface to form a sensing layer. A temperature increase to a value higher than the volume phase transition temperature led to a substantial increase in the amperometric signal. That behavior was well switchable. The signal was linearly dependent on glucose concentration in the physiological concentration range. It appeared that the synthesized and functionalized microgel was a kind of microreactor and might be very useful for the construction of the platforms that can enhance the activity of enzymes in biosensors.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorStojek, Zbigniew
dc.contributor.authorMaćkiewicz, Marcin
dc.contributor.authorKarbarz, Marcin
dc.contributor.authorKaniewska, Klaudia
dc.contributor.authorRomański, Jan
dc.contributor.authorMarcisz, Kamil
dc.contributor.authorNowińska, Anna
dc.date.accessioned2024-01-24T22:33:00Z
dc.date.available2024-01-24T22:33:00Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.number12
dc.description.volume30
dc.identifier.doi10.1002/ELAN.201800459
dc.identifier.issn1040-0397
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/105961
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofElectroanalysis
dc.relation.pages2853-2860
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enelectroactive microgel
dc.subject.enmediating matrix
dc.subject.englucose oxidase
dc.subject.enpoly(N-isopropylacrylamide)
dc.titleElectroactive, mediating and thermosensitive microgel useful for covalent entrapment of enzymes and formation of sensing layer in biosensors
dc.typeJournalArticle
dspace.entity.typePublication