Artykuł w czasopiśmie
Brak miniatury
Licencja
CC-BYCC-BY - Uznanie autorstwa
 

Native Structure-Based Peptides as Potential Protein–Protein Interaction Inhibitors of SARS-CoV-2 Spike Protein and Human ACE2 Receptor

Uproszczony widok
dc.abstract.enSevere acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a positive-strand RNA virus that causes severe respiratory syndrome in humans, which is now referred to as coronavirus disease 2019 (COVID-19). Since December 2019, the new pathogen has rapidly spread globally, with over 65 million cases reported to the beginning of December 2020, including over 1.5 million deaths. Unfortunately, currently, there is no specific and effective treatment for COVID-19. As SARS-CoV-2 relies on its spike proteins (S) to bind to a host cell-surface receptor angiotensin-converting enzyme-2(ACE2), and this interaction is proved to be responsible for entering a virus into host cells, it makes an ideal target for antiviral drug development. In this work, we design three very short peptides based on the ACE2 sequence/structure fragments, which may effectively bind to the receptor-binding domain (RBD) of S protein and may, in turn, disrupt the important virus-host protein–protein interactions, blocking early steps of SARS-CoV-2 infection. Two of our peptides bind to virus protein with affinity in nanomolar range, and as very short peptides have great potential for drug development.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorMarzec, Ewa
dc.contributor.authorPoznański, Jarosław
dc.contributor.authorWiniewska-Szajewska, Maria
dc.contributor.authorZielenkiewicz, Piotr
dc.contributor.authorOdolczyk, Norbert
dc.date.accessioned2024-01-25T13:30:30Z
dc.date.available2024-01-25T13:30:30Z
dc.date.copyright2021-04-09
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number8
dc.description.versionFINAL_PUBLISHED
dc.description.volume26
dc.identifier.doi10.3390/MOLECULES26082157
dc.identifier.issn1420-3049
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/113369
dc.identifier.weblinkhttps://www.mdpi.com/1420-3049/26/8/2157/pdf
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofMolecules
dc.relation.pages2157
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enSARS-CoV-2
dc.subject.enCOVID-19
dc.subject.eninhibitors of protein–protein interactions
dc.subject.enpeptides
dc.subject.endrug design
dc.subject.encoronavirus
dc.subject.enangiotensin-converting enzyme-2
dc.subject.enACE2
dc.titleNative Structure-Based Peptides as Potential Protein–Protein Interaction Inhibitors of SARS-CoV-2 Spike Protein and Human ACE2 Receptor
dc.typeJournalArticle
dspace.entity.typePublication