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Dostęp zamkniętyPhysicochemical Characterization of Sparsely Tethered Bilayer Lipid Membranes: Structure of Submembrane Water and Nanomechanical Properties
| cris.lastimport.scopus | 2024-02-12T20:38:24Z |
| dc.abstract.en | Sparsely tethered bilayer lipid membrane (stBLM) is a popular model considered to mimic biological membranes. The advantage of this system is the molecular architecture that provides a water environment on both sides of the lipid membrane. In this work, we have coupled electrochemical measurements with surface-enhanced infrared absorption spectroscopy and atomic force microscopy to evaluate the effect of the electric field on the physicochemical properties of stBLM composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine and cholesterol. More specifically, we have focused on the structure of the submembrane water and nanomechanical properties of the membrane. Our experimental results revealed that stBLM composed of DMPC/Cholesterol offers good nanomechanical stability and low permeability within a relatively wide potential window. Importantly, it also covers biologically relevant range corresponding to transmembrane potentials occurring in natural cell membranes, which makes them suitable platform for bioinspired sensing devices. |
| dc.affiliation | Uniwersytet Warszawski |
| dc.contributor.author | Sęk, Sławomir |
| dc.contributor.author | Dziubak, Damian |
| dc.date.accessioned | 2024-01-25T16:37:30Z |
| dc.date.available | 2024-01-25T16:37:30Z |
| dc.date.issued | 2021 |
| dc.description.finance | Publikacja bezkosztowa |
| dc.description.number | 13 |
| dc.description.volume | 8 |
| dc.identifier.doi | 10.1002/CELC.202100721 |
| dc.identifier.uri | https://repozytorium.uw.edu.pl//handle/item/115888 |
| dc.identifier.weblink | https://onlinelibrary.wiley.com/doi/pdf/10.1002/celc.202100721 |
| dc.language | eng |
| dc.pbn.affiliation | chemical sciences |
| dc.relation.ispartof | ChemElectroChem |
| dc.relation.pages | 2564-2571 |
| dc.rights | ClosedAccess |
| dc.sciencecloud | nosend |
| dc.subject.en | electrochemistry |
| dc.subject.en | sparsely tethered bilayers lipid membranes |
| dc.subject.en | surface enhanced infrared absorption spectroscopy |
| dc.subject.en | atomic force microscopy |
| dc.subject.en | biosensing |
| dc.title | Physicochemical Characterization of Sparsely Tethered Bilayer Lipid Membranes: Structure of Submembrane Water and Nanomechanical Properties |
| dc.type | JournalArticle |
| dspace.entity.type | Publication |