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Flavin‐Helicene Amphiphilic Hybrids: Synthesis, Characterization, and Preparation of Surface‐Supported Films

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cris.lastimport.scopus2024-02-12T20:38:36Z
dc.abstract.enThis work reports on the preparation and structural characterization of flavo[7]helicene 1 (flavin-[7]helicene conjugate), which was subsequently characterized at the molecular level in either an aqueous environment or an organic phase, at the supramolecular level in the form of polymeric layers, and also embedded in a lipidic mesophase environment to study the resulting properties of such a hybrid relative to its parent molecules. The flavin benzo[g]pteridin-2,4-dione (isoalloxazine) was selected for conjugation because of its photoactivity and reversible redox behavior. Compound 1 was prepared from 2-nitroso[6]helicene and 6-methylamino-3-methyluracil, and characterized using common structural and spectroscopic tools: circular dichroism (CD), circularly polarized luminescence (CPL) spectroscopy, cyclic voltammetry (CV), and DFT quantum calculations. In addition, a methodology that allows the loading of 1 enantiomers into an internally nanostructured lipid (1-monoolein) matrix was developed.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBilewicz, Renata
dc.contributor.authorCytryniak, Adrianna
dc.contributor.authorVacek, Jan
dc.contributor.authorStorch, Jan
dc.contributor.authorŽádný, Jaroslav
dc.contributor.authorCísařová, Ivana
dc.contributor.authorCrassous, Jeanne
dc.contributor.authorHrbáč, Jan
dc.contributor.authorCibulka, Radek
dc.contributor.authorFavereau, Ludovic
dc.contributor.authorZatloukalová, Martina
dc.contributor.authorJakubec, Martin
dc.contributor.authorNovák, David
dc.date.accessioned2024-01-25T01:13:31Z
dc.date.available2024-01-25T01:13:31Z
dc.date.issued2021
dc.description.financePublikacja bezkosztowa
dc.identifier.doi10.1002/CPLU.202100092
dc.identifier.issn2192-6506
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/107263
dc.identifier.weblinkhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/cplu.202100092
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofChemPlusChem
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleFlavin‐Helicene Amphiphilic Hybrids: Synthesis, Characterization, and Preparation of Surface‐Supported Films
dc.typeJournalArticle
dspace.entity.typePublication