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DNA damage, repair and the improvement of cancer therapy – A tribute to the life and research of Barbara Tudek.

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cris.lastimport.scopus2024-02-12T20:48:19Z
dc.abstract.enProfessor Barbara Tudek received the Frits Sobels Award in 2019 from the European Environmental Mutagenesis and Genomics Society (EEMGS). This article presents her outstanding character and most important lines of research. The focus of her studies covered alkylative and oxidative damage to DNA bases, in particular mutagenic and carcinogenic properties of purines with an open imidazole ring and 8-oxo-7,8-dihydroguanine (8-oxoGua). They also included analysis of mutagenic properties and pathways for the repair of DNA adducts of lipid peroxidation (LPO) products arising in large quantities during inflammation. Professor Tudek did all of this in the hope of deciphering the mechanisms of DNA damage removal, in particular by the base excision repair (BER) pathway. Some lines of research aimed at discovering factors that can modulate the activity of DNA damage repair in hope to enhance existing anti-cancer therapies. The group's ongoing research aims at deciphering the resistance mechanisms of cancer cell lines acquired following prolonged exposure to photodynamic therapy (PDT) and the possibility of re-sensitizing cells to PDT in order to increase the application of this minimally invasive therapeutic method.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBorsuk, Ewelina M.
dc.contributor.authorBażlekowa-Karaban, Milena
dc.contributor.authorZDŻALIK-BIELECKA, DARIA
dc.contributor.authorCzerwińska, Jolanta
dc.contributor.authorTudek, Agnieszka
dc.contributor.authorSpeina, Elżbieta
dc.contributor.authorKosicki, Konrad
dc.contributor.authorGhahe, Somayeh Shahmoradi
dc.date.accessioned2024-01-24T22:11:26Z
dc.date.available2024-01-24T22:11:26Z
dc.date.issued2020
dc.description.financePublikacja bezkosztowa
dc.description.volume852
dc.identifier.doi10.1016/J.MRGENTOX.2020.503160
dc.identifier.issn1383-5718
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/105105
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S1383571820300309?via%3Dihub
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofMutation Research - Genetic Toxicology and Environmental Mutagenesis
dc.relation.pages503160
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enAging
dc.subject.enCancer
dc.subject.enDNA damage
dc.subject.enDNA repair
dc.subject.enLipid peroxidation
dc.subject.enOxidative stress
dc.titleDNA damage, repair and the improvement of cancer therapy – A tribute to the life and research of Barbara Tudek.
dc.typeJournalArticle
dspace.entity.typePublication