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Single-step synthesis of Er3+ and Yb3+ ions doped molybdate/Gd2O3 core-shell nanoparticles for biomedical imaging

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dc.abstract.enNanostructures as color-tunable luminescent markers have become major, promising tools for bioimaging and biosensing. In this paper separated molybdate/Gd2O3 doped rare earth ions (erbium, Er3+ and ytterbium, Yb3+) core-shell nanoparticles (NPs), were fabricated by a one-step homogeneous precipitation process. Emission properties were studied by cathodo- and photoluminescence. Scanning electron and transmission electron microscopes were used to visualize and determine the size and shape of the NPs. Spherical NPs were obtained. Their core-shell structures were confirmed by x-ray diffraction and energy-dispersive x-ray spectroscopy measurements. We postulated that the molybdate rich core is formed due to high segregation coefficient of the Mo ion during the precipitation. The calcination process resulted in crystallization of delta/xi (core/shell) NP doped Er and Yb ions, where delta-gadolinium molybdates and xi-molybdates or gadolinium oxide. We confirmed two different upconversion mechanisms. In the presence of molybdenum ions, in the core of the NPs, Yb3+-MoO4-2 (vertical bar F-2(7/2), T-3(2)>) dimers were formed. As a result of a two 980 nm photon absorption by the dimer, we observed enhanced green luminescence in the upconversion process. However, for the shell formed by the Gd2O3:Er, Yb NPs (without the Mo ions), the typical energy transfer upconversion takes place, which results in red luminescence. We demonstrated that the NPs were transported into cytosol of the HeLa and astrocytes cells by endocytosis. The core-shell NPs are sensitive sensors for the environment prevailing inside (shorter luminescence decay) and outside (longer luminescence decay) of the tested cells. The toxicity of the NPs was examined using MTT assay.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSikora, Bożena
dc.contributor.authorZajdel, Karolina
dc.contributor.authorFrontczak-Baniewicz, Małgorzata
dc.contributor.authorZaleszczyk, Wojciech
dc.contributor.authorPaszkowicz, Wojciech
dc.contributor.authorStępień, Piotr
dc.contributor.authorWILCZYŃSKI, GRZEGORZ
dc.contributor.authorKamińska, Izabela
dc.contributor.authorFelcyn, Zofia
dc.contributor.authorKowalik, Przemysław
dc.contributor.authorŁapiński, Mariusz
dc.contributor.authorSzewczyk, Maciej
dc.contributor.authorSamol, Piotr
dc.contributor.authorMinikayev, Roman
dc.contributor.authorWojciechowski, Tomasz
dc.contributor.authorMikulski, Jakub
dc.contributor.authorFronc, Krzysztof
dc.contributor.authorKonopka, Anna
dc.contributor.authorDonten, Mikołaj
dc.contributor.authorCiszak, Kamil
dc.contributor.authorElbaum, Danek
dc.contributor.authorPawlyta, Mirosława
dc.contributor.authorGruzeł, Grzegorz
dc.date.accessioned2024-01-26T07:39:03Z
dc.date.available2024-01-26T07:39:03Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.number2
dc.description.volume29
dc.identifier.doi10.1088/1361-6528/AA9974
dc.identifier.issn0957-4484
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/119877
dc.identifier.weblinkhttps://iopscience.iop.org/article/10.1088/1361-6528/aa9974
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofNanotechnology
dc.relation.pagesart.no. 25702-1-19
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.encore-shell nanoparticles
dc.subject.enupconversion molybdates
dc.subject.enGd2O3
dc.subject.enHeLa cells
dc.subject.enastrocytes MTT
dc.titleSingle-step synthesis of Er3+ and Yb3+ ions doped molybdate/Gd2O3 core-shell nanoparticles for biomedical imaging
dc.typeJournalArticle
dspace.entity.typePublication