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To Tie or Not to Tie? That Is the Question

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dc.abstract.enIn this review, we provide an overview of entangled proteins. Around 6% of protein structures deposited in the PBD are entangled, forming knots, slipknots, lassos and links. We present theoretical methods and tools that enabled discovering and classifying such structures. We discuss the advantages and disadvantages of the non-trivial topology in proteins, based on available data about folding, stability, biological properties and evolutionary conservation. We also formulate intriguing and challenging questions on the border of biophysics, bioinformatics, biology and mathematics, which arise from the discovery of an entanglement in proteins. Finally, we discuss possible applications of entangled proteins in medicine and nanotechnology, such as the chance to design super stable proteins, whose stability could be controlled by chemical potential.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorDąbrowski-Tumański, Paweł
dc.contributor.authorSułkowska, Joanna
dc.date.accessioned2024-01-26T11:04:30Z
dc.date.available2024-01-26T11:04:30Z
dc.date.issued2017
dc.description.financeNie dotyczy
dc.identifier.doi10.3390/POLYM9090454
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/123623
dc.languageeng
dc.pbn.affiliationphysical sciences
dc.relation.ispartofPolymers
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleTo Tie or Not to Tie? That Is the Question
dc.typeJournalArticle
dspace.entity.typePublication