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Anticancer agents found in environment affect Daphnia at population, individual and molecular levels

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dc.abstract.enPharmaceuticals are used in medical treatment on a large scale and as a waste contaminate freshwater ecosystems. Growing amount of so-called civilization diseases, such as different type of cancer, significantly contribute to this form of pollution. The aim of the present study was to determine how the exposure to chemotherapeutics: cyclophosphamide (CP) and cisplatin (CDDP), at detected in environment concentrations, influence proteome profile, life history and population parameters of naturally setting surface waters Daphnia pulex and Daphnia pulicaria. The parameters important for crustaceans, survivorship and population growth rate, were importantly decreased by CDDP treatment but not influenced by CP. On the contrary, the individual growth rate was affected only by CP and exclusively in the case of D. pulicaria. In both clones treated with CP or CDDP, decreased number of eggs was observed. Interestingly, Daphnia males were less sensitive to tested chemotherapeutic than females. Proteome profile revealed that tested anticancer pharmaceuticals modified expression of some proteins involved in Daphnia metabolism. Moreover, males exposed to CDDP showed increased level of enzymes participating in DNA repair. Summing up, the contaminating environment chemotherapeutics reduced fitness of naturally occurring Daphnia species. In consequence this may affect functioning of the aquatic food webs.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorPilżys, Tomasz
dc.contributor.authorGrzesiuk, Elżbieta
dc.contributor.authorMalinowska, Agata
dc.contributor.authorGarbicz, Damian
dc.contributor.authorMielecki, Damian
dc.contributor.authorŚwiderska, Bianka
dc.contributor.authorGrzesiuk-Bieniek, Małgorzata
dc.contributor.authorMarcinkowski, Michał
dc.contributor.authorBednarska, Anna
dc.date.accessioned2024-01-24T16:40:12Z
dc.date.available2024-01-24T16:40:12Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.description.volume215
dc.identifier.doi10.1016/J.AQUATOX.2019.105288
dc.identifier.issn0166-445X
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/100777
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/abs/pii/S0166445X19304059?via%3Dihub
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofAquatic Toxicology
dc.relation.pages1-9
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enpharmaceuticals
dc.subject.enalkylating agents
dc.subject.encyclophosphamide
dc.subject.encisplatin
dc.subject.enlife history
dc.subject.enproteome
dc.titleAnticancer agents found in environment affect Daphnia at population, individual and molecular levels
dc.typeJournalArticle
dspace.entity.typePublication