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Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas

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dc.abstract.enChromatin structure and accessibility, and combinatorial binding of transcription factors to regulatory elements in genomic DNA control transcription. Genetic variations in genes encoding histones, epigenetics-related enzymes or modifiers affect chromatin structure/dynamics and result in alterations in gene expression contributing to cancer development or progression. Gliomas are brain tumors frequently associated with epigenetics-related gene deregulation. We perform whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples to unravel epigenetic dysfunctions driving gliomagenesis. Based on the results of the integrative analysis of the acquired profiles, we create an atlas of active enhancers and promoters in benign and malignant gliomas. We explore these elements and intersect with Hi-C data to uncover molecular mechanisms instructing gene expression in gliomas.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGuzik, Rafał
dc.contributor.authorRoszkowski, Marcin
dc.contributor.authorJardanowska, Marta
dc.contributor.authorStępniak, Karolina
dc.contributor.authorDziedzic, Agata
dc.contributor.authorKotulska-Jóźwiak, Katarzyna
dc.contributor.authorMarchel, Andrzej
dc.contributor.authorCzernicki, Tomasz
dc.contributor.authorKranas, Hanna
dc.contributor.authorDiamanti, Klev
dc.contributor.authorSienkiewicz, Karolina
dc.contributor.authorGrajkowska, Wiesława
dc.contributor.authorDramiński, Michał
dc.contributor.authorGrabowicz, Ilona
dc.contributor.authorWilczyński, Bartosz
dc.contributor.authorKomorowski, Henryk
dc.contributor.authorDąbrowski, Michał
dc.contributor.authorMachnicka, Magdalena
dc.contributor.authorWojtaś, Bartosz
dc.contributor.authorPerycz, Małgorzata
dc.contributor.authorMacioszek, Anna
dc.contributor.authorKamińska-Kaczmarek, Bożena
dc.contributor.authorMieczkowski, Jakub
dc.contributor.authorGielniewski, Bartłomiej
dc.contributor.authorKról, sylwia
dc.contributor.authorPoleszak, Katarzyna
dc.date.accessioned2024-01-25T05:32:49Z
dc.date.available2024-01-25T05:32:49Z
dc.date.copyright2021-06-14
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financeŚrodki finansowe przyznane na realizację projektu w zakresie badań naukowych lub prac rozwojowych
dc.description.number1
dc.description.versionFINAL_PUBLISHED
dc.description.volume12
dc.identifier.doi10.1038/S41467-021-23922-2
dc.identifier.issn2041-1723
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/111803
dc.identifier.weblinkhttp://www.nature.com/
dc.languageeng
dc.pbn.affiliationcomputer and information sciences
dc.relation.ispartofNature Communications
dc.relation.pages1-17
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enCancer genomics
dc.subject.enEpigenetics
dc.subject.enTranscriptomics
dc.titleMapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas
dc.typeJournalArticle
dspace.entity.typePublication