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Mass transfer of anti-cancer drug delivery to brain tumours by a multiple emulsion-based implant

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cris.lastimport.scopus2024-02-12T20:46:31Z
dc.abstract.enThe advanced use of a pH-responsive biomaterial-based injectable liquid implant for effective chemotherapeutic delivery in glioblastoma multiforme brain (GBM) tumour treatment is presented. As an implant, we proposed a water-in-oil-in-water multiple emulsion with encapsulated doxorubicin. The effectiveness of the proposed therapy was evaluated by comparing the cancer cell viability achieved in classical therapy (chemotherapeutic solution). The experimental study included doxorubicin release rates and consumption for two emulsions differing in drop sizes and structures in the presence of GBM-cells (LN229, U87 MG), and a cell viability. The results showed that the multiple emulsion implant was significantly more effective than classical therapy when considering the reduction in cancer cell viability: 85% for the emulsion-implant, and only 43% for the classical therapy. A diffusion-reaction model was adapted to predict doxorubicin release kinetics and elimination by glioblastoma cells. CFD simulations confirmed that the drug release kinetics depends on multiple emulsion structures and drop sizes.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKosicki, Konrad
dc.contributor.authorRudniak, Leszek
dc.contributor.authorMetera, Agata
dc.contributor.authorMarkowska-Radomska, Agnieszka
dc.contributor.authorDłuska, Ewa
dc.date.accessioned2024-01-25T05:33:56Z
dc.date.available2024-01-25T05:33:56Z
dc.date.copyright2021-10-12
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number2
dc.description.versionFINAL_PUBLISHED
dc.description.volume68
dc.identifier.doi10.1002/AIC.17501
dc.identifier.issn0001-1541
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/111894
dc.identifier.weblinkhttps://aiche.onlinelibrary.wiley.com/doi/epdf/10.1002/aic.17501
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofAICHE Journal
dc.relation.pages1-15
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enbiomedical engineering
dc.subject.encomputational fluid dynamics (cfd)
dc.subject.encontrolled drug delivery
dc.subject.endiffusion
dc.subject.enmass transfer
dc.subject.enrelease
dc.titleMass transfer of anti-cancer drug delivery to brain tumours by a multiple emulsion-based implant
dc.typeJournalArticle
dspace.entity.typePublication