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Polypyrrole microcapsules loaded with gold nanoparticles: Perspectives for biomedical imaging

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dc.abstract.enWe report the facile preparation of polypyrrole microcapsules with a hydrophobic liquid core that is loaded with gold nanoparticles. Through the oxidative polymerization of pyrrole, the polymer is deposited onto the surface of the droplets, which results in the encapsulation of both the liquid phase and the metal nanoparticles. We demonstrate the preparation of the microcapsules loaded with organic solvents (toluene, hexane) or 2-oxoheptyl isothiocyanate (new promising anticancer agent) as the liquid cores and stable or radioactive gold nanoparticles (Au-197 or Au-198 isotopes). The resulting microcapsules have been demonstrated as promising agents for medical applications such as computed tomography or gamma imaging. Moreover, the capsules can be applied as drug carriers, which has been shown in vitro on cancer and normal cell cultures.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorChotkowski, Maciej
dc.contributor.authorGłowala, Paulina
dc.contributor.authorMazur, Maciej
dc.contributor.authorDorant, Sylwia
dc.contributor.authorMojzych, Ilona
dc.contributor.authorKwiatkowska, Marta
dc.contributor.authorKaczyńska, Katarzyna
dc.contributor.authorKrug, Pamela
dc.contributor.authorWiktorska, Katarzyna
dc.contributor.authorStolarski, Jarosław
dc.contributor.authorJaniszewska, Katarzyna
dc.contributor.authorKępińska, Daria
dc.date.accessioned2024-01-25T17:02:40Z
dc.date.available2024-01-25T17:02:40Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.description.volume248
dc.identifier.doi10.1016/J.SYNTHMET.2018.12.025
dc.identifier.issn0379-6779
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/116480
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/abs/pii/S0379677918304284?via%3Dihub
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofSynthetic Metals
dc.relation.pages27-34
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enPolypyrrole microcapsules
dc.subject.enGold nanoparticles doped with Au-198
dc.subject.enTargeted drug delivery
dc.subject.enComputed tomography
dc.subject.enGamma imaging
dc.subject.enAnticancer agents
dc.titlePolypyrrole microcapsules loaded with gold nanoparticles: Perspectives for biomedical imaging
dc.typeJournalArticle
dspace.entity.typePublication