Artykuł w czasopiśmie
Brak miniatury
Licencja
CC-BYCC-BY - Uznanie autorstwa
 

Synthesis, characterization, and interactions of single-walled carbon nanotubes modified with doxorubicin with Langmuir–Blodgett biomimetic membranes

Uproszczony widok
cris.lastimport.scopus2024-02-12T20:46:54Z
dc.abstract.enThe synthesis, characterization, and the influence of single-walled carbon nanotubes (SWCNTs) modified with an anticancer drug doxorubicin (DOx) on the properties of model biological membrane as well as the comparison of the two modes of modification has been presented. The drug was covalently attached to the nanotubes either preferentially on the sides or at the ends of the nanotubes by the formation of hydrazone bond. The efficiency of the modification was proved by the results of FTIR, Raman, and thermogravimetric analysis. In order to characterize the influence of SWCNT-DOx conjugates on model biological membranes, Langmuir technique has been employed. The mixed monolayers composed of 1,2-dipalmitoyl-sn-glycero-3-phosphothioethanol (DPPTE) and SWCNT-DOx with different weight ratio have been prepared. It has been shown that changes in the isotherm characteristics depend on the SWCNTs content. While smaller amounts of SWCNTs do not exert significant differences, the introduction of the prevailing content of the nanotubes increases area per molecule and decreases the maximum value of compression modulus, leading to more fluid monolayer. However, upon increasing the surface pressure, the aggregation of carbon nanotubes within the thiolipid matrix has been observed. Mixed layers of DPPTE/SWCNT-DOx were also transferred onto gold electrodes by means of LB method. Cyclic voltammetry showed that SWCNT-DOx conjugates remain adsorbed at the electrode surface and are stable in time. Additionally, higher values of peak current and DOx surface concentration obtained for side modification prove that side modification allows for more efficient conjugation of the drug to carbon nanotubes.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBilewicz, Renata
dc.contributor.authorSadowska, Kamila
dc.contributor.authorBiernat, Jan F.
dc.contributor.authorNapora, Ewelina
dc.contributor.authorMatyszewska, Dorota
dc.date.accessioned2024-01-26T09:26:36Z
dc.date.available2024-01-26T09:26:36Z
dc.date.copyright2018-05-12
dc.date.issued2018
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number5
dc.description.versionFINAL_PUBLISHED
dc.description.volume20
dc.identifier.doi10.1007/S11051-018-4239-X
dc.identifier.issn1388-0764
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/121293
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofJournal of Nanoparticle Research
dc.relation.pagesart.no. 143
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.en1,2-dipalmitoyl-sn-glycero-3-phosphothioethanol (DPPTE)
dc.subject.enDoxorubicin (DOx)
dc.subject.enSingle-walled carbon nanotubes (SWCNTs)
dc.subject.enDrug carriers
dc.subject.enModel lipid membranes
dc.titleSynthesis, characterization, and interactions of single-walled carbon nanotubes modified with doxorubicin with Langmuir–Blodgett biomimetic membranes
dc.typeJournalArticle
dspace.entity.typePublication