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Hypothalamic Neurochemical Changes in Long-Term Recovered Bilateral Subdiaphragmatic Vagotomized Rats

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dc.abstract.enBackground: Vagus nerve is one of the crucial routes in communication between the immune and central nervous systems. The impaired vagal nerve function may intensify peripheral inflammatory processes. This effect subsides along with prolonged recovery after permanent nerve injury. One of the results of such compensation is a normalized plasma concentration of stress hormone corticosterone – a marker of hypothalamic-pituitary-adrenal (HPA) axis activity. In this work, we strive to explain this corticosterone normalization by studying the mechanisms responsible for compensation-related neurochemical alterations in the hypothalamus. Materials and Methods: Using microarrays and high performance liquid chromatography (HPLC), we measured genome-wide gene expression and major amino acid neurotransmitters content in the hypothalamus of bilaterally vagotomized rats, 1 month after surgery. Results: Our results show that, in the long term, vagotomy affects hypothalamic amino acids concentration but not mRNA expression of tested genes. Discussion: We propose an alternative pathway of immune to CNS communication after vagotomy, leading to activation of the HPA axis, by influencing central amino acids and subsequent monoaminergic neurotransmission.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGóra, Monika
dc.contributor.authorBurzyńska, Beata
dc.contributor.authorWieczorek, Marek
dc.contributor.authorPierzchala-Koziec, Krystyna
dc.contributor.authorIwanicka-Nowicka, Roksana
dc.contributor.authorGoscik, Joanna
dc.contributor.authorStankiewicz, Adrian Mateusz
dc.contributor.authorKobrzycka, Anna Teresa
dc.date.accessioned2024-01-25T03:32:02Z
dc.date.available2024-01-25T03:32:02Z
dc.date.copyright2022-07-08
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.numberbrak
dc.description.versionFINAL_PUBLISHED
dc.description.volume16
dc.identifier.doi10.3389/FNBEH.2022.869526
dc.identifier.issn1662-5153
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108817
dc.identifier.weblinkhttps://www.frontiersin.org/articles/10.3389/fnbeh.2022.869526/full
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofFrontiers in Behavioral Neuroscience
dc.relation.pages869526 (1-8)
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enhypothalamus, s
dc.subject.enubdiaphragmatic vagotomy,
dc.subject.enamino acid neurotransmitters,
dc.subject.eninflammatory response,
dc.subject.enmicroarray,
dc.subject.enHPA axis
dc.titleHypothalamic Neurochemical Changes in Long-Term Recovered Bilateral Subdiaphragmatic Vagotomized Rats
dc.typeJournalArticle
dspace.entity.typePublication