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Aromaticity of nucleic acid bases

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dc.abstract.en3D shape and the resulting physicochemical properties of double-helical DNA/RNA structures are determined not only by individual nucleobases, but also by their additive intermolecular interactions. Energetic contribution from aromatic π–π stacking to the stabilization of DNA/RNA is not small and sometimes even comparable to that from H-bonding. The basis of the stacking interactions lies in the π-electron structure of individual nucleobases, which can be described by various aromaticity indices. Heteroatoms and exocyclic functional groups make the electronic structure of nucleobases different from aromatic hydrocarbons. Consequently, the cyclic π-electron delocalization is not the only factor responsible for the relative stability of their tautomers. This review puts the spotlight on interplay between aromaticity of purine and pyrimidine nucleobases and their tautomeric preferences, as well as on the effects of different noncovalent interactions (hydrogen bonding, metal ion coordination, and π–π stacking) on π-electron delocalization of five- and six-membered rings in individual nucleobases and their complexes.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSola, Miquel
dc.contributor.authorSzatyłowicz, Halina
dc.contributor.authorStasyuk, Olga
dc.contributor.authorKrygowski, Tadeusz
dc.date.accessioned2024-01-24T16:56:19Z
dc.date.available2024-01-24T16:56:19Z
dc.date.issued2021
dc.description.financePublikacja bezkosztowa
dc.description.number4
dc.description.volume11
dc.identifier.doi10.1002/WCMS.1509
dc.identifier.issn1759-0876
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/101139
dc.identifier.weblinkhttps://onlinelibrary.wiley.com/doi/full/10.1002/wcms.1509?af=R
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofWiley Interdisciplinary Reviews: Computational Molecular Science
dc.relation.pages1-21
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleAromaticity of nucleic acid bases
dc.typeJournalArticle
dspace.entity.typePublication