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Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers

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dc.abstract.enCardiovascular diseases (CVD) is a collective term describing a range of conditions that affect the heart and blood vessels. Due to the varied nature of the disorders, distinguishing between their causes and monitoring their progress is crucial for finding an effective treatment. Molecular imaging enables non-invasive visualisation and quantification of biological pathways, even at the molecular and subcellular levels, what is essential for understanding the causes and development of CVD. Positron emission tomography imaging is so far recognized as the best method for in vivo studies of the CVD elated phenomena. The imaging is based on the use of radioisotope-labelled markers, which have been successfully used in both pre-clinical research and clinical studies. Current research on CVD with the use of such radioconjugates constantly increases our knowledge and understanding of the causes, and brings us closer to effective monitoring and treatment. This review outlines recent advances in the use of the so-far available radioisotope markers in the research on cardiovascular diseases in rodent models, points out the problems and provides a perspective for future applications of PET imaging in CVD studies.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorRogulski, Zbigniew
dc.contributor.authorRozwadowska, Natalia
dc.contributor.authorUhrynowski, Witold
dc.contributor.authorWargocka-Matuszewska, Weronika
dc.date.accessioned2024-01-25T18:47:59Z
dc.date.available2024-01-25T18:47:59Z
dc.date.copyright2022-12-26
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number1
dc.description.versionFINAL_PUBLISHED
dc.description.volume24
dc.identifier.doi10.3390/IJMS24010353
dc.identifier.issn1422-0067
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/117954
dc.identifier.weblinkhttps://www.mdpi.com/1422-0067/24/1/353/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.pages353
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enpositron emission tomography (PET)
dc.subject.encardiovascular diseases (CVD)
dc.subject.enmolecular imaging
dc.subject.enradioisotope marker
dc.subject.enanimal model
dc.titleRecent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers
dc.typeJournalArticle
dspace.entity.typePublication