Artykuł w czasopiśmie
Brak miniatury
Licencja
CC-BYCC-BY - Uznanie autorstwa
 

Immunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense

Uproszczony widok
cris.lastimport.scopus2024-02-12T20:35:53Z
dc.abstract.enHuman African trypanosomiasis (HAT) is a neglected tropical disease that is caused by flagellated parasites of the genus Trypanosoma. HAT imposes a significant socio-economic burden on many countries in sub-Saharan Africa and its control is hampered by several drawbacks ranging from the ineffectiveness of drugs, complex dosing regimens, drug resistance, and lack of a vaccine. Despite more than a century of research and investigations, the development of a vaccine to tackle HAT is still challenging due to the complex biology of the pathogens. Advancements in computational modeling coupled with the availability of an unprecedented amount of omics data from different organisms have allowed the design of new generation vaccines that offer better antigenicity and safety profile. One of such new generation approaches is a multi-epitope vaccine (MEV) designed from a collection of antigenic peptides. A MEV can stimulate both cellular and humoral immune responses as well as avoiding possible allergenic reactions. Herein, we take advantage of this approach to design a MEV from conserved hypothetical plasma membrane proteins of Trypanosoma brucei gambiense, the trypanosome subspecies that is responsible for the west and central African forms of HAT. The designed MEV is 402 amino acids long (41.5 kDa). It is predicted to be antigenic, non-toxic, to assume a stable 3D conformation, and to interact with a key immune receptor. In addition, immune simulation foresaw adequate immune stimulation by the putative antigen and a lasting memory. Therefore, the designed chimeric vaccine represents a potential candidate that could be used to target HAT
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGórna, Maria
dc.contributor.authorBalogun, Emmanuel Oluwadare
dc.contributor.authorDibba, Lamin BS
dc.contributor.authorIdris, Salisu
dc.contributor.authorGital, Salahuddin Iliyasu
dc.contributor.authorDanazumi, Ammar Usman
dc.date.accessioned2024-01-25T03:44:38Z
dc.date.available2024-01-25T03:44:38Z
dc.date.copyright2022-11-07
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financeŚrodki finansowe, o których mowa w art. 365 pkt. 2 ustawy
dc.description.versionFINAL_PUBLISHED
dc.description.volume20
dc.identifier.doi10.1016/J.CSBJ.2022.10.002
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108979
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S2001037022004494?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofComputational and Structural Biotechnology Journal
dc.relation.pages5574-5585
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enBioinformatics
dc.subject.enChimeric antigen
dc.subject.enImmunoinformatics
dc.subject.enMulti-epitope vaccine
dc.subject.enTransmembrane proteins
dc.subject.enTrypanosomiasis
dc.titleImmunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense
dc.typeJournalArticle
dspace.entity.typePublication