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The ligand exchange of citrates to thioabiraterone on gold nanoparticles for prostate cancer therapy

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dc.abstract.enCancer is one of the leading causes of morbidity and mortality worldwide and nanotechnology has a significant otential to enhance the therapeutic and diagnostic performance of anti-cancer agents. Our work offers a simple and feasible strategy for thiocompound nanomedicines to be used in cancer therapy. Novel gold nanoparticles onjugated with thioabiraterone (AuNP-S-AB) were synthesized and significant new analytical methodologies were developed for their characterization by UV–Vis, TEM, IR, NMR and TGA. Our synthetic approach was based on the ligand xchange of citrates to thioabiraterone on gold nanoparticles. The average particle size of AuNP-SAB was 14.5 nm with a spherical shape. The identity of thioabiraterone on the gold nanoparticles was proved by NMR and IR pectroscopy. The coverage of the gold nanoparticles with 40.9% (m/m) thioabiraterone was calculated from a TGA analysis. Molecular interactions between the thiol group of thioabiraterone and gold nanoparticles were evaluated through a combined experimental and theoretical study using the density functional theory (DFT). itionally, an experiment conducted on hepatocytes or human prostate epithelial cells proved that newly synthesized thiol forms of abiraterone, as well as AuNP-S-AB, are more biocompatible than abiraterone. Our proposed idea of delivering abiraterone with our newly designed AuNP-S-AB may constitute a promising and novel prospect in cancer therapy.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorStolarczyk, Elżbieta U.
dc.contributor.authorSidoryk, Katarzyna
dc.contributor.authorŁaszcz, Marta
dc.contributor.authorStrzempek, Weronika
dc.contributor.authorKubiszewski, Marek
dc.contributor.authorFusaro, Massimo
dc.contributor.authorMenaszek, Elżbieta
dc.contributor.authorStolarczyk, Krzysztof
dc.contributor.authorLEŚ, ANDRZEJ
dc.date.accessioned2024-01-26T10:27:16Z
dc.date.available2024-01-26T10:27:16Z
dc.date.issued2020
dc.description.financePublikacja bezkosztowa
dc.description.volume583
dc.identifier.doi10.1016/J.IJPHARM.2020.119319
dc.identifier.issn0378-5173
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/122635
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S0378517320303033?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.relation.pages119319
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enAuNPs-gold nanoparticles
dc.subject.enHS-AB - thiolated abiraterone (thioabiraterone)
dc.subject.enDFT – density functional theory
dc.subject.enHepG2 cells
dc.subject.enPNT-2 cells
dc.titleThe ligand exchange of citrates to thioabiraterone on gold nanoparticles for prostate cancer therapy
dc.typeJournalArticle
dspace.entity.typePublication