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Voltammetric/UV–Vis study of temozolomide inclusion complexes with cyclodextrin derivatives

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cris.lastimport.scopus2024-02-12T20:36:18Z
dc.abstract.enTemozolomide (TMZ) – a chemotherapeutic agent possessing cytotoxic activity is used in single or combined therapies of human glioma. Difficulties in these applications, connected with low solubility and stability of temozolomide lead us to study the inclusion complexes between TMZ, and three cyclodextrins: b-cyclodextrin (bCD), monodeoxy-6-monoamino-b-cyclodextrin hydrochloride (bCDamine), and b-cyclodextrin containing galactosamine and triazole ring in the side group (bCDgal). The voltammetric and spectroscopy studies showed the improvement of the drug solubility and formation of stable complexes. Higuchi and Connors method was used to determine the solubilities of the drug in the presence of the selected cyclodextrins. Phase solubility diagrams showed increase of TMZ solubility and 1:1 stoichiometry of the complexes formed. The stability constant of TMZ- bCDgal complex was pH – dependent, larger at pH 7.4 (corresponding to the pH of the body fluids), than at pH 5.5, characteristic for the cancer cells environment. bCDgal ligand was an effective complexing agent for TMZ due to additional strong proton-acceptor p-p interactions between the triazole ring of the cyclodextrin and the ring of TMZ. The increased solubility and sustainability of TMZ complexes with bCDgal allow to propose this cyclodextrin as a promising TMZ carrier for further studies in the biological cell environment.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBilewicz, Renata
dc.contributor.authorKrzak, Agata
dc.date.accessioned2024-01-26T11:49:46Z
dc.date.available2024-01-26T11:49:46Z
dc.date.copyright2020-06-26
dc.date.issued2020
dc.description.accesstimeAT_PUBLICATION
dc.description.financeŚrodki finansowe, o których mowa w art. 365 pkt. 2 ustawy
dc.description.versionFINAL_PUBLISHED
dc.description.volume136
dc.identifier.doi10.1016/J.BIOELECHEM.2020.107587
dc.identifier.issn1567-5394
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/124698
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S1567539419307170?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofBioelectrochemistry
dc.relation.pages107587
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.subject.enTemozolomide
dc.subject.enCyclodextrin
dc.subject.enPhase-solubility diagram
dc.subject.enInclusion complex
dc.titleVoltammetric/UV–Vis study of temozolomide inclusion complexes with cyclodextrin derivatives
dc.typeJournalArticle
dspace.entity.typePublication