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Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle

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cris.lastimport.scopus2024-02-12T20:35:33Z
dc.abstract.enCoralyne is a synthetic analog of berberine related to protoberberine-isoquinoline alkaloids. Isoquinoline derivatives and analogs are renowned as potent radiosensitizers with potential medical application. In the present study, we investigated the effect of coralyne on the cell death, cytoskeletal changes and cell cycle progression of irradiated A549 cells. A clonogenic assay revealed that coralyne pretreatment decreased the viability of A549 cells in a time- and dose-dependent manner. Moreover, exposure to coralyne and ionizing radiation (IR) markedly altered the filamentous actin cytoskeletal architecture and integrin-β binding sites of A549 cells. Treatment with 1–25 µM coralyne in combination with 2 Gy of IR significantly reduced the percentage of cells in G2/M phase compared with 2 Gy IR alone. These results indicate that coralyne is a potent radiosensitizing agent that may find an application in medicine.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorLis, Krzysztof
dc.contributor.authorWasilewska, Malwina
dc.contributor.authorCiepluch, Karol
dc.contributor.authorLisowska, Halina
dc.contributor.authorArabski, Michał
dc.contributor.authorStępkowski, Tomasz
dc.contributor.authorLankoff, Anna
dc.contributor.authorWęgierek-Ciuk, Aneta
dc.contributor.authorBrzóska, Kamil
dc.date.accessioned2024-01-24T20:48:17Z
dc.date.available2024-01-24T20:48:17Z
dc.date.copyright2021-05-28
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number11
dc.description.versionFINAL_PUBLISHED
dc.description.volume22
dc.identifier.doi10.3390/IJMS22115791
dc.identifier.issn1422-0067
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/103761
dc.identifier.weblinkhttps://www.mdpi.com/1422-0067/22/11/5791/pdf
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.pages5791
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enCoralyne
dc.subject.enCellular uptake
dc.subject.enCell cycle progression
dc.subject.enGene and protein expression
dc.subject.enCytoskeletal alterations
dc.subject.enCell death
dc.titleCoralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle
dc.typeJournalArticle
dspace.entity.typePublication