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Time-Resolved Thickness and Shape-Change Quantification using a Dual-Band Nanoplasmonic Ruler with Sub-Nanometer Resolution

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dc.abstract.enTime-resolved measurements of changes in the size and shape of nanobiological objects and layers are crucial to understand their properties and optimize their performance. Optical sensing is particularly attractive with high throughput and sensitivity, and label-free operation. However, most state-of-the-art solutions require intricate modeling or multiparameter measurements to disentangle conformational or thickness changes of biomolecular layers from complex interfacial refractive index variations. Here, we present a dual-band nanoplasmonic ruler comprising mixed arrays of plasmonic nanoparticles with spectrally separated resonance peaks. As electrodynamic simulations and model experiments show, the ruler enables real-time simultaneous measurements of thickness and refractive index variations in uniform and heterogeneous layers with sub-nanometer resolution. Additionally, nanostructure shape changes can be tracked, as demonstrated by quantifying the degree of lipid vesicle deformation at the critical coverage prior to rupture and supported lipid bilayer formation. In a broader context, the presented nanofabrication approach constitutes a generic route for multimodal nanoplasmonic optical sensing.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorLanghammer, Christoph
dc.contributor.authorAntosiewicz, Tomasz
dc.contributor.authorHöök, Fredrik
dc.contributor.authorZhdanov, Vladimir P.
dc.contributor.authorNilsson, Sara
dc.contributor.authorDarmadi, Iwan
dc.contributor.authorO’Reilly, Padraic
dc.contributor.authorArmanious, Antonius
dc.contributor.authorŚwitlik, Dominika
dc.contributor.authorNugroho, Ferry Anggoro Ardy
dc.date.accessioned2024-01-26T10:53:37Z
dc.date.available2024-01-26T10:53:37Z
dc.date.issued2022
dc.description.financePublikacja bezkosztowa
dc.description.number10
dc.description.volume16
dc.identifier.doi10.1021/ACSNANO.2C04948
dc.identifier.issn1936-0851
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/123428
dc.identifier.weblinkhttps://pubs.acs.org/doi/pdf/10.1021/acsnano.2c04948
dc.languageeng
dc.pbn.affiliationphysical sciences
dc.relation.ispartofACS Nano
dc.relation.pages15814-15826
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.ensupported lipid bilayer
dc.subject.enbiomolecules
dc.subject.enbiosensors
dc.subject.enconformation
dc.subject.ennanoplasmonic sensors
dc.subject.ennanorulers
dc.titleTime-Resolved Thickness and Shape-Change Quantification using a Dual-Band Nanoplasmonic Ruler with Sub-Nanometer Resolution
dc.typeJournalArticle
dspace.entity.typePublication