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Enantioselective sensing of (S)-Thalidomide in blood plasma with a chiral naphthalene diimide derivative

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dc.abstract.enFast, simple in use and highly effective voltammetric enantiosensor dedicated for determination of thalidomide (TD) enantiomers (especially towards the toxic (S)-enantiomer) in blood plasma is still desirable. Here we have proven that newly synthesized chiral naphthalene diimide (NDI) derivatives are excellent electroactive materials for TD enantiosensors. The recognition process relies on the specific interaction between the chiral NDI receptor and the thalidomide enantiomer of the opposite configuration. This unique specific interaction between (S)-thalidomide and (R)-NDI derivative counterparts, evident in the DPV voltammograms, was confirmed by molecular modeling. The demonstrated voltammetric enantiosensors are characterized by the low detection limit at the level of μg·L−1, wide analytical range from 5·10−4 – 10 mg·L−1, high selectivity and long lifetime. The results of the recovery rates showed a very good degree of accuracy towards the determination of (S)-thalidomide in the blood samples, so it can be successfully used in the analysis of clinical samples.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorDonten, Mikołaj
dc.contributor.authorPoszytek, Joanna
dc.contributor.authorLipiński, Piotr
dc.contributor.authorMalkowska, Anna
dc.contributor.authorGrudzinski, Ireneusz P.
dc.contributor.authorKaroń, Krzysztof
dc.contributor.authorKawęcki, Robert
dc.contributor.authorŁapkowski, Mieczysław
dc.contributor.authorNowicka, Anna
dc.contributor.authorRode, Joanna
dc.contributor.authorDobrowolski, Jan
dc.contributor.authorKowalczyk, Agata
dc.contributor.authorŁyczko, Krzysztof
dc.contributor.authorKaczorek, Dorota
dc.date.accessioned2024-01-24T22:47:31Z
dc.date.available2024-01-24T22:47:31Z
dc.date.issued2020
dc.description.financePublikacja bezkosztowa
dc.description.volume167
dc.identifier.doi10.1016/J.BIOS.2020.112446
dc.identifier.issn0956-5663
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/106158
dc.identifier.weblinkhttp://www.journals.elsevier.com/biosensors-and-bioelectronics/
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofBiosensors and Bioelectronics
dc.relation.pagesart.no. 112446
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enThalidomide
dc.subject.enVoltammetric enantiosensor
dc.subject.enChiral naphthalene diimide
dc.subject.enChiral recognition modeling
dc.titleEnantioselective sensing of (S)-Thalidomide in blood plasma with a chiral naphthalene diimide derivative
dc.typeJournalArticle
dspace.entity.typePublication